Formic Acid → 2-(N-methylformamido)-4-methyl-5-acetylthiazole
반응식
[CH3:1][NH:2][C:3]1[S:4][C:5]([C:9](=[O:11])[CH3:10])=[C:6]([CH3:8])[N:7]=1.[C:12](OC(=O)C)(=[O:14])C.C(O)=O>O1CCCC1>[CH3:1][N:2]([C:3]1[S:4][C:5]([C:9](=[O:11])[CH3:10])=[C:6]([CH3:8])[N:7]=1)[CH:12]=[O:14]참가 물질
5
실험 절차
To a solution of 2-methylamino-4-methyl-5-acetylthiazole (35 g) in tetrahydrofuran (700 ml) were added a mixture of acetic anhydride (94.5 ml) and formic acid (37.7 ml) at ambient temperature and the mixture was stirred for two hours. The reaction mixture was evaporated in vacuo. The residue was added to water and the resultant precipitate was collected by filtration and dried over phosphorus pentoxide to give 2-(N-methylformamido)-4-methyl-5-acetylthiazole (39.59 g).
후처리
- customThe reaction mixture was evaporated in vacuo
- additionThe residue was added to water
- filtrationthe resultant precipitate was collected by filtration
- dry with materialdried over phosphorus pentoxide
출처 및 근거
- ORD 기록
- ord-884dbaa5b4494834b8bee2ff882716a7
- 출처 데이터셋
- uspto-grants-1987_03
- 특허 번호
- US04649146
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