Ethylenediamine → N-[2-(amino)ethyl]-2-(3-hydroxy-2oxo-1-pyrrolidinyl)acetamide

반응식

[OH:1][CH:2]1[CH2:6][CH2:5][N:4]([CH2:7][C:8]([O:10]CC)=O)[C:3]1=[O:13].[CH2:14]([NH2:17])[CH2:15][NH2:16]>>[NH2:16][CH2:15][CH2:14][NH:17][C:8](=[O:10])[CH2:7][N:4]1[CH2:5][CH2:6][CH:2]([OH:1])[C:3]1=[O:13]

참가 물질

반응물 2

HCID 3301Ethylenediamine

HCID 13385945ethyl (R/S)-2-(3-hydroxy-2oxo-1-pyrrolidinyl)acetate

생성물 1

HCID 19817649N-[2-(amino)ethyl]-2-(3-hydroxy-2oxo-1-pyrrolidinyl)acetamide

실험 절차

A mixture of 3.5 g of ethyl (R/S)-2-(3-hydroxy-2-oxo-1-pyrrolidinyl)acetate and 11.2 g of 1,2-ethylenediamine is left to stand at room temperature for 20 hours. The excess 1,2-ethylenediamine is evaporated in vacuo. The residue is dissolved in 40 ml of hot acetonitrile and stirred at room temperature for 2 hours and then in an ice-bath for 1 hour. By filtration there is isolated N-[2-(amino)ethyl]-2-(3-hydroxy-2oxo-1-pyrrolidinyl)acetamide of melting point 110°-112°.

후처리

waitis left
customThe excess 1,2-ethylenediamine is evaporated in vacuo
dissolutionThe residue is dissolved in 40 ml of hot acetonitrile
waitin an ice-bath for 1 hour
filtrationBy filtration

출처 및 근거

ORD 기록: ord-b10d534f31004bb0800c48c358ca9f30
출처 데이터셋: uspto-grants-1987_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04650878

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