Hydrochloric Acid → HCID 13826432, 화합물

HRID 1906924노트

반응식

HRID 1906924 반응식
[Cl:1][C:2]1[C:11]2[CH2:10][CH2:9][CH2:8][C:7](=[O:12])[C:6]=2[C:5]([CH2:13][CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])=[C:4]([CH3:20])[CH:3]=1.Cl.S(Cl)([Cl:25])(=O)=O>C(Cl)Cl>[Cl:1][C:2]1[C:11]2[CH2:10][CH2:9][CH:8]([Cl:25])[C:7](=[O:12])[C:6]=2[C:5]([CH2:13][CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])=[C:4]([CH3:20])[CH:3]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 24648Sulfuryl chlorideHCID 13826430HCID 13826430, 화합물

생성물 1

HCID 13826432HCID 13826432, 화합물수율 95.8%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of ethyl 3-(4-chloro-2-methyl-8-oxo-5,6,7,8-tetrahydronaphthalen-1-yl)propanoate (5.70 g, 20.3 mmoles) in CH2Cl2 (20 ml) was saturated with dry gaseous HCl and sulfuryl chloride (16.4 ml, 27.5 g, 203 mmoles) was added dropwise and stirred at room temperature for 2 hours. The solvent and excess sulfuryl chloride were evaporated in vacuo then chased with dry toluene two times to leave 6.40 g of title compound as a gum. Exact mass calculated for C16H17O3Cl (parent-HCl): 292.0866; Found: 292.0869

후처리

  1. additionwas added dropwise
  2. customThe solvent and excess sulfuryl chloride were evaporated in vacuo

출처 및 근거

ORD 기록
ord-066b2796f69e479896e5f6b8d87d4e6b
출처 데이터셋
uspto-grants-1987_03
특허 번호
US04654363

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