HCID 53944659, 화합물 → 2-(Morpholin-4-yl)pyrimidine-5-carboxylic acid

HRID 1907707노트

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HRID 1907707 반응식
[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[N:12]=[CH:11][C:10]([C:13]([O:15]CC)=[O:14])=[CH:9][N:8]=2)[CH2:3][CH2:2]1>Cl.O>[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[N:8]=[CH:9][C:10]([C:13]([OH:15])=[O:14])=[CH:11][N:12]=2)[CH2:3][CH2:2]1

참가 물질

4

반응물 1

HCID 53944659HCID 53944659, 화합물

생성물 1

HCID 31609792-(Morpholin-4-yl)pyrimidine-5-carboxylic acid수율 107.3%

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 962Water용매

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온도
-78 °C

실험 절차

A solution of ester 122 (0.205 g, 0.86 mmol) in 2N HCl in H2O (10 mL) was stirred at 110° C. in a pressure vessel for 6 h, cooled to −78° C. and lyophilized for 2 days. The resulting amorphous solid was further dried using a mixture of dry acetonitrile (10 mL) and dry benzene (10 mL) followed by concentration (this was repeated 3 times) to give compound 123 (0.193 g, 92% yield). LRMS: 209.1 (calc) 210.0 (obs).

후처리

  1. customThe resulting amorphous solid was further dried
  2. additiona mixture of dry acetonitrile (10 mL) and dry benzene (10 mL)
  3. concentrationfollowed by concentration (

출처 및 근거

ORD 기록
ord-6e224ce6bbbc4b14ae7d568535675e76
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08598168B2

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