Hydrochloric Acid → HCID 178479578, 화합물

HRID 1908276노트

반응식

HRID 1908276 반응식
[CH:1]1([NH:4][C:5](=[O:24])[CH:6]([OH:23])[CH:7]([NH:15]C(=O)OC(C)(C)C)[CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH2:3][CH2:2]1.[ClH:25].CO>ClCCl>[Cl-:25].[CH:1]1([NH:4][C:5](=[O:24])[CH:6]([OH:23])[CH:7]([NH3+:15])[CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH2:2][CH2:3]1

참가 물질

5

반응물 3

HCID 313Hydrochloric Acid2회HCID 887MethanolHCID 66645006Tert-butyl 4-(cyclopropylamino)-3-hydroxy-4-oxo-1-phenylbutan-2-ylcarbamate

생성물 1

HCID 178479578HCID 178479578, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

tert-Butyl 4-(cyclopropylamino)-3-hydroxy-4-oxo-1-phenylbutan-2-ylcarbamate (780 mg, 2.332 mmol) in dichloromethane (30 ml) was stirred together with 2 ml of HCl (4 m solution in dioxane) for 3 h at room temperature, then 1 ml of HCl and 5 ml of methanol were added and the reaction mixture stirred over night. The mixture was concentrated under reduced pressure, co-evaporated 2× with toluene, the remainder then treated with n-pentane and dried to give 550 mg of a white solid; ESI-MS [M+H]+: 235.1.

후처리

  1. concentrationThe mixture was concentrated under reduced pressure
  2. additionthe remainder then treated with n-pentane
  3. customdried

출처 및 근거

ORD 기록
ord-2e326e834778453da808db0acf876a40
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08598211B2

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