Potassium Permanganate → HCID 67027109, 화합물

HRID 1908809노트

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HRID 1908809 반응식
[Br:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([CH2:9][OH:10])[CH:3]=1.[O-:11][Mn](=O)(=O)=O.[K+:16]>CC(C)=O>[K+:16].[Br:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([C:9]([O-:11])=[O:10])[CH:3]=1

참가 물질

4

반응물 2

HCID 516875Potassium PermanganateHCID 67027007(4-Bromo-6-methylpyridin-2-yl)methanol

생성물 1

HCID 67027109HCID 67027109, 화합물수율 116%

시약·촉매·용매 1

HCID 180Acetone용매

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온도
40 °C

실험 절차

To a solution of (4-bromo-6-methyl-pyridin-2-yl)-methanol (1.31 g, 6.48 mmol) in acetone (150 mL), KMnO4 (2.61 g, 16.5 mmol) is added. The mixture is stirred at 40° C. for 2 h before it is filtered over a sintered glass funnel. The filtrate is evaporated to dryness, the remaining solid is washed with water and dried under HV to give 4-bromo-6-methyl-pyridine-2-carboxylic acid potassium salt (1.91 g) as a white solid; LC-MS: tR=0.45 min, [M+1]+=217.89.

후처리

  1. filtrationis filtered over a sintered glass funnel
  2. customThe filtrate is evaporated to dryness
  3. washthe remaining solid is washed with water
  4. customdried under HV

출처 및 근거

ORD 기록
ord-b33b130f2686450eab5df7b6cf7d7ac1
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08598208B2

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