Diethyl Malonate → 4-((4,6-Dihydroxypyrimidin-2-yl)amino)benzonitrile

HRID 1908949노트

반응식

HRID 1908949 반응식
[C:1]([O:9]CC)(=O)[CH2:2][C:3]([O:5]CC)=O.[C:12]([C:14]1[CH:19]=[CH:18][C:17]([NH:20][C:21]([NH2:23])=[NH:22])=[CH:16][CH:15]=1)#[N:13].[Na]>C(O)C>[OH:9][C:1]1[CH:2]=[C:3]([OH:5])[N:23]=[C:21]([NH:20][C:17]2[CH:18]=[CH:19][C:14]([C:12]#[N:13])=[CH:15][CH:16]=2)[N:22]=1

참가 물질

5

반응물 3

HCID 7761Diethyl MalonateHCID 5360545SodiumHCID 178510065HCID 178510065, 화합물

생성물 1

HCID 1785100404-((4,6-Dihydroxypyrimidin-2-yl)amino)benzonitrile수율 93.6%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Diethyl malonate (30 gm) was added to 1-(4-cyanophenyl)guanidine (30 gm) at room temperature. A solution of sodium (17.2 gm) in ethanol (450 ml) was added to the above reaction mass. The contents were heated to reflux and maintained for 12 hours. Distilled off the solvent completely under vacuum and then added water (500 ml). The reaction mass was stirred for 30 minutes and filtered. The solid obtained was dried to obtain 40 gm of 4-(4,6-dihydroxypyrimidine-2-yl-amino)benzonitrile.

후처리

  1. temperatureThe contents were heated
  2. temperatureto reflux
  3. temperaturemaintained for 12 hours
  4. distillationDistilled off the solvent completely under vacuum
  5. filtrationfiltered
  6. customThe solid obtained
  7. customwas dried

출처 및 근거

ORD 기록
ord-db95016f3c0e4cf9bc49e189d4ebbc5c
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08598341B2

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