Hydrochloric Acid → HCID 178479251, 화합물

HRID 1909359노트

반응식

HRID 1909359 반응식
C(OC(=O)[NH:7][C@H:8]1[CH2:13][CH2:12][C@H:11]([CH2:14][CH2:15][N:16]2[CH2:21][CH2:20][CH:19]([C:22]3[C:30]4[O:29][CH2:28][O:27][C:26]=4[CH:25]=[CH:24][CH:23]=3)[CH2:18][CH2:17]2)[CH2:10][CH2:9]1)(C)(C)C.[ClH:32]>ClCCl>[ClH:32].[O:27]1[C:26]2[CH:25]=[CH:24][CH:23]=[C:22]([CH:19]3[CH2:20][CH2:21][N:16]([CH2:15][CH2:14][C@H:11]4[CH2:10][CH2:9][C@H:8]([NH2:7])[CH2:13][CH2:12]4)[CH2:17][CH2:18]3)[C:30]=2[O:29][CH2:28]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 178453890HCID 178453890, 화합물

생성물 1

HCID 178479251HCID 178479251, 화합물수율 100%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a mixture of trans-{4-[2-(4-Benzo[1,3]dioxol-4-yl-piperidin-1-yl)-ethyl]-cyclohexyl}-carbamic acid tert-butyl ester (1.06 g, 2.46 mmol,) in dichloromethane (15 ml) was added at room temperature hydrochloric acid solution (4M in dioxane, 6.15 ml, 24.6 mmol,) and the mixture was allowed to stir for 4 h, the solvent was evaporated, diisopropyl ether (15 ml) were added and the mixture was allowed to stir for 10 min at room temperature. The precipitate was collected by filtration, washed with diisopropyl ether and dried to yield the title compound as a white solid (0.954, 100%), MS m/z=330.23 [(M)+].

후처리

  1. customthe solvent was evaporated
  2. additiondiisopropyl ether (15 ml) were added
  3. stirringto stir for 10 min at room temperature
  4. filtrationThe precipitate was collected by filtration
  5. washwashed with diisopropyl ether
  6. customdried

출처 및 근거

ORD 기록
ord-9d44c3033fdc4780b4d8bf4a8e5997f7
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08598357B2

반응 노트

불러오는 중…