Hydrochloric Acid → (r)-Piperidin-2-ylmethanol hydrochloride

HRID 1909682노트

반응식

HRID 1909682 반응식
[ClH:1].C(OC([N:9]1[CH2:14][CH2:13][CH2:12][CH2:11][C@@H:10]1[CH2:15][OH:16])=O)(C)(C)C>O1CCOCC1>[ClH:1].[NH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][C@@H:10]1[CH2:15][OH:16]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 6933953tert-butyl (2R)-2-(hydroxymethyl)piperidine-1-carboxylate

생성물 1

HCID 67247105(r)-Piperidin-2-ylmethanol hydrochloride

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

A 4M HCl solution in dioxane (30 mL) was added to (R)-2-Hydroxymethyl-piperidine-1-carboxylic acid tert-butyl ester (4.65 g, 21.6 mmol). The mixture was stirred at rt for 3 h. The solvent was removed in vacuo to yield the title product as a hydrochloride salt (3.47 g).

후처리

  1. customThe solvent was removed in vacuo

출처 및 근거

ORD 기록
ord-891def3f501f403390e67261d0ae1a72
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08598359B2

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