N-bromobutanimide → 5-Bromo-4-chloro-7-methyl-7H-pyrrolo(2,3-d)pyrimidine
반응식
[Cl:1][C:2]1[C:3]2[CH:10]=[CH:9][N:8]([CH3:11])[C:4]=2[N:5]=[CH:6][N:7]=1.C1C(=O)N([Br:19])C(=O)C1>ClCCl>[Br:19][C:10]1[C:3]2[C:2]([Cl:1])=[N:7][CH:6]=[N:5][C:4]=2[N:8]([CH3:11])[CH:9]=1참가 물질
4
실험 절차
To 4-chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine (12.15 g, 72.5 mmol) in Dichloromethane (DCM) (200 mL) was added NBS (13.55 g, 76 mmol) portionwise, and the reaction mixture was stirred overnight at room temperature. The solvent was evaporated, and the solid was washed with water and dried to afford 5-bromo-4-chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine (17 g) as an off-white solid.
후처리
- customThe solvent was evaporated
- washthe solid was washed with water
- customdried
출처 및 근거
- ORD 기록
- ord-92316150a0524002954de3a3b1b347a4
- 출처 데이터셋
- uspto-grants-2013_12
- 특허 번호
- US08598156B2
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