Hydrochloric Acid → phenylmethyl [2-(4-amino-3-{1-[(2,5-difluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl}furo[3,2-c]pyridin-7-yl)ethyl]carbamate

HRID 1910029

반응식

HRID 1910029 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[CH2:9][C:10]([N:12]1[C:20]2[C:15](=[CH:16][C:17]([C:21]3[C:25]4[C:26]([N:43](C(OC(C)(C)C)=O)C(OC(C)(C)C)=O)=[N:27][CH:28]=[C:29]([CH2:30][CH2:31][NH:32][C:33]([O:35][CH2:36][C:37]5[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=5)=[O:34])[C:24]=4[O:23][CH:22]=3)=[CH:18][CH:19]=2)[CH2:14][CH2:13]1)=[O:11].Cl.O1CCOCC1>>[C:37]1([CH2:36][O:35][C:33](=[O:34])[NH:32][CH2:31][CH2:30][C:29]2[C:24]3[O:23][CH:22]=[C:21]([C:17]4[CH:16]=[C:15]5[C:20](=[CH:19][CH:18]=4)[N:12]([C:10](=[O:11])[CH2:9][C:3]4[CH:4]=[C:5]([F:8])[CH:6]=[CH:7][C:2]=4[F:1])[CH2:13][CH2:14]5)[C:25]=3[C:26]([NH2:43])=[N:27][CH:28]=2)[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=1

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 66823788bis(1,1-dimethylethyl) {3-{1-[(2,5-difluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl}-7-[2-({[(phenylmethyl)oxy]carbonyl}amino)ethyl]furo[3,2-c]pyridin-4-yl}imidodicarbonate

생성물 1

HCID 69939762phenylmethyl [2-(4-amino-3-{1-[(2,5-difluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl}furo[3,2-c]pyridin-7-yl)ethyl]carbamate수율 85.3%

실험 절차

A mixture of bis(1,1-dimethylethyl) {3-{1-[(2,5-difluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl}-7-[2-({[(phenylmethyl)oxy]carbonyl}amino)ethyl]furo[3,2-c]pyridin-4-yl}imidodicarbonate (149 mg, 0.190 mmol) and 4.0 M HCl in dioxane (2.0 mL, 8.00 mmol) was stirred at room temperature under Nitrogen for 4 hr. The crude reaction mixture was then concentrated in vacuo and azeotroped once with acetonitrile. The residue was taken up in DCM and passed through a PL-HCO3 MP-resin cartridge, rinsing with more DCM. The filtrate was then concentrated in vacuo to give the free base of phenylmethyl[2-(4-amino-3-{1-[(2,5-difluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl}furo[3,2-c]pyridin-7-yl)ethyl]carbamate (105 mg, 0.162 mmol, 85% yield) as an off-white foam (purity estimated at 90%). LC/MS (ES) m/z=583.6 [M+H]+. 1H NMR (400 MHz, DMSO-d6) d 2.86 (t, J=7.07 Hz, 2H), 3.22-3.34 (m, 4H), 3.96 (s, 2H), 4.31 (t, J=8.34 Hz, 2H), 5.02 (s, 2H), 5.38 (s, 2H), 7.14-7.44 (m, 12H), 7.68 (s, 1H), 7.93 (s, 1H), 8.12 (d, J=8.34 Hz, 1H).

후처리

  1. customThe crude reaction mixture
  2. concentrationwas then concentrated in vacuo
  3. customazeotroped once with acetonitrile
  4. washrinsing with more DCM
  5. concentrationThe filtrate was then concentrated in vacuo

출처 및 근거

ORD 기록
ord-2fab4b7a7fbd4f66b994c35599d0d281
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08598156B2

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