Magnesium peroxide (Mg(O2)) → 4-Methyl-1-phenylisoquinoline

HRID 1910341

반응식

HRID 1910341 반응식
[O-][O-].[Mg+2].[C:4]1([C:10]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH:13]([CH3:20])[CH2:12][N:11]=2)[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1>C1C=CC=CC=1>[C:4]1([C:10]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[C:13]([CH3:20])=[CH:12][N:11]=2)[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

참가 물질

4

반응물 2

HCID 61745Magnesium peroxide (Mg(O2))HCID 131435804-Methyl-1-phenyl-3,4-dihydroisoquinoline

생성물 1

HCID 128434954-Methyl-1-phenylisoquinoline수율 42.5%

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

To a suspension of activated magnesium dioxide (270 g, 0.132 mol) in 550 mL of benzene was added 1-phenyl-4-methyl-3,4-dihydroisoquinoline (29.0 g, 0.131 mol) with stirring. The reaction mixture was heated at reflux for 16 hours. The magnesium dioxide was removed by vacuum filtration and washed with methylene chloride. Evaporation of the solvent yielded 12.2 g (42%) of pure yellow crystals of 1-phenyl-4-methylisoquinoline.

후처리

  1. temperatureThe reaction mixture was heated
  2. temperatureat reflux for 16 hours
  3. customThe magnesium dioxide was removed by vacuum filtration
  4. washwashed with methylene chloride
  5. customEvaporation of the solvent

출처 및 근거

ORD 기록
ord-713ee148d584444f812fc7d9b29f8c64
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08603645B2

연결된 노트

불러오는 중…