Hydrochloric Acid → 4-methoxy-4-(1-methyl-1H-imidazol-2-yl)piperidine dihydrochloride

HRID 1910392노트

반응식

HRID 1910392 반응식
[CH3:1][O:2][C:3]1([C:16]2[N:17]([CH3:21])[CH:18]=[CH:19][N:20]=2)[CH2:8][CH2:7][N:6](C(OC(C)(C)C)=O)[CH2:5][CH2:4]1.[ClH:22]>CCOC(C)=O.O>[ClH:22].[ClH:22].[CH3:1][O:2][C:3]1([C:16]2[N:17]([CH3:21])[CH:18]=[CH:19][N:20]=2)[CH2:4][CH2:5][NH:6][CH2:7][CH2:8]1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 68570558tert-butyl 4-methoxy-4-(1-methyl-1H-imidazol-2-yl)piperidine-1-carboxylate

생성물 1

HCID 685712034-methoxy-4-(1-methyl-1H-imidazol-2-yl)piperidine dihydrochloride

시약·촉매·용매 2

HCID 962Water용매HCID 8857Ethyl Acetate용매2회

실험 절차

To a solution of tert-butyl 4-methoxy-4-(1-methyl-1H-imidazol-2-yl)piperidine-1-carboxylate (182 mg) in EtOAc (0.7 ml) and water (0.09 ml) was added 4N hydrogen chloride in EtOAc (0.7 ml) and the mixture was stirred at room temperature for 2 hours. Solvent was removed in vacuo to give 4-methoxy-4-(1-methyl-1H-imidazol-2-yl)piperidine dihydrochloride (122 mg) as a colorless powder. The obtained crude product was used in next reaction without further purification.

후처리

  1. customSolvent was removed in vacuo

출처 및 근거

ORD 기록
ord-7bc64af39f604b6d96b2599468b9f6b9
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08603975B2

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