Hydrochloric Acid → 4-(1-methyl-1H-imidazol-2-yl)piperidine dihydrochloride

HRID 1910395노트

반응식

HRID 1910395 반응식
[CH3:1][N:2]1[CH:6]=[CH:5][N:4]=[C:3]1[CH:7]1[CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9][CH2:8]1.[ClH:20]>CCOC(C)=O>[ClH:20].[ClH:20].[CH3:1][N:2]1[CH:6]=[CH:5][N:4]=[C:3]1[CH:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 23084145Tert-butyl 4-(1-methyl-1H-imidazol-2-yl)piperidine-1-carboxylate

생성물 1

HCID 685712954-(1-methyl-1H-imidazol-2-yl)piperidine dihydrochloride

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매2회

실험 절차

To a solution of tert-butyl 4-(1-methyl-1H-imidazol-2-yl)piperidine-1-carboxylate (132 mg) in EtOAc (1.3 ml) was added 4N hydrogen chloride in EtOAc (1.3 ml) and the mixture was stirred at room temperature for 2 hours. Solvent was removed in vacuo to give 4-(1-methyl-1H-imidazol-2-yl)piperidine dihydrochloride (108 mg) as a colorless powder. The obtained crude product was used in next reaction without further purification.

후처리

  1. customSolvent was removed in vacuo

출처 및 근거

ORD 기록
ord-3866ff2a5a974e58b6f524dc76d4c426
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08603975B2

반응 노트

불러오는 중…