Water → tert-butyl [(2R)-2-methoxypropyl]carbamate
반응식
[OH:1][C@H:2]([CH3:12])[CH2:3][NH:4][C:5](=[O:11])[O:6][C:7]([CH3:10])([CH3:9])[CH3:8].[CH3:13]N(C)C1C2C(=CC=CC=2N(C)C)C=CC=1.F[B-](F)(F)F.C[O+](C)C.O>C(Cl)Cl>[CH3:13][O:1][C@H:2]([CH3:12])[CH2:3][NH:4][C:5](=[O:11])[O:6][C:7]([CH3:8])([CH3:10])[CH3:9]참가 물질
6
실험 절차
To a solution of tert-butyl [(2R)-2-hydroxypropyl]carbamate (2.7 g) in CH2Cl2 (41 ml) were added N,N,N′,N′-tetramethylnaphthalene-1,8-diamine (3.63 g) and trimethyloxonium tetrafluoroborate (2.51 g), and the whole was stirred for 3 hours at room temperature. Water was added to the mixture, and the whole was extracted with EtOAc, and the extract was washed with water and brine and dried over MgSO4. Concentration under reduced pressure gave tert-butyl [(2R)-2-methoxypropyl]carbamate (2.73 g).
후처리
- extractionthe whole was extracted with EtOAc
- washthe extract was washed with water and brine
- dry with materialdried over MgSO4
- concentrationConcentration under reduced pressure
출처 및 근거
- ORD 기록
- ord-85518414f53d4eac964b9ef51eb66f51
- 출처 데이터셋
- uspto-grants-2013_12
- 특허 번호
- US08603975B2
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