Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl 5-(2-bromoacetyl)isoxazole-3-carboxylate → 3-((Bis(3-fluorophenyl)methoxy)carbonyl)-1-(2-(3-(ethoxycarbonyl)isoxazol-5-yl)-2-oxoethyl)-1-azoniabicyclo[2.2.2]octane bromide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl 5-(2-bromoacetyl)isoxazole-3-carboxylate | HCID 2736373 | — |
| 반응물 | Bis(3-fluorophenyl)methyl quinuclidine-3-carboxylate | HCID 70925896 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 3-((Bis(3-fluorophenyl)methoxy)carbonyl)-1-(2-(3-(ethoxycarbonyl)isoxazol-5-yl)-2-oxoethyl)-1-azoniabicyclo[2.2.2]octane bromide | HCID 86672940 | 17.5% |
반응 단계
Bis(3-fluorophenyl)methyl quinuclidine-3-carboxylate (86 mg, 0.24 mmol, prepared as in example 4) and ethyl 5-(2-bromoacetyl)isoxazole-3-carboxylate (69.4 mg, 0.26 mmol) were dissolved in acetonitrile (3 ml) and stirred at room temperature overnight. The precipitated was recovered by suction filtration to obtain 3-((bis(3-fluorophenyl)methoxy)carbonyl)-1-(2-(3-(ethoxycarbonyl)isoxazol-5-yl)-2-oxoethyl)-1-azoniabicyclo[2.2.2]octane bromide (26 mg, racemic mixture).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08604015B2 |
| 출처 데이터셋 | uspto-grants-2013_12 |
| ORD ID | ord-9ef1597c26f24f4ea802ba9f803442c6 |
| 출처 메모 | uspto-grants-2013_12 |