Hydrochloric Acid → 2-(Piperazin-1-yl)propan-1-ol

HRID 1911412노트

반응식

HRID 1911412 반응식
[OH:1][CH2:2][CH:3]([N:5]1[CH2:10][CH2:9][N:8](C(OC(C)(C)C)=O)[CH2:7][CH2:6]1)[CH3:4].Cl.O1CCOCC1>C(OCC)(=O)C.CO.CCOCC>[N:5]1([CH:3]([CH3:4])[CH2:2][OH:1])[CH2:10][CH2:9][NH:8][CH2:7][CH2:6]1

참가 물질

7

반응물 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 50987509Tert-butyl 4-(1-hydroxypropan-2-yl)piperazine-1-carboxylate

생성물 1

HCID 706292-(Piperazin-1-yl)propan-1-ol수율 113.8%

시약·촉매·용매 3

HCID 887Methanol용매HCID 3283Diethyl Ether용매HCID 8857Ethyl Acetate용매

실험 절차

A suspension of tert-butyl 4-(1-hydroxypropan-2-yl)piperazine-1-carboxylate (0.782 g, 3.2 mmol) in a mixture of ethyl acetate (10 ml) and methanol (10.00 mL), was treated drop-wise with 4.0M HCl in dioxane (12.00 ml, 48.00 mmol) at room temperature. The reaction mixture was stirred for 18 h. The reaction mixture was diluted with ether and the white solid filtered off, washed with ether and air dried to give 2-(piperazin-1-yl)propan-1-ol (0.525 g, 76%), as its dihydrochloride salt.

후처리

  1. filtrationthe white solid filtered off
  2. washwashed with ether and air
  3. customdried

출처 및 근거

ORD 기록
ord-9bcf92eded784b58a2c9bca317f02da0
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08604022B2

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