Water → HCID 59799786, 화합물

HRID 1911907노트

반응식

HRID 1911907 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[C:11]([NH2:15])=[N:12][O:13][N:14]=2)=[CH:6][CH:5]=1)([O-])=O.[Sn](Cl)Cl.O>C(OCC)(=O)C>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([C:10]2[C:11]([NH2:15])=[N:12][O:13][N:14]=2)=[CH:8][CH:9]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 24479Stannous ChlorideHCID 14021895HCID 14021895, 화합물

생성물 1

HCID 59799786HCID 59799786, 화합물수율 94%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

4-(4-Nitrophenyl)-1,2,5-oxadiazol-3-amine (0.500 g, 2.42 mmol), tin dichloride (1.61 g, 8.49 mmol), and water (0.306 mL, 17.0 mmol) were combined in ethyl acetate (20 mL) in a round bottom flask, and the mixture was stirred at room temperature overnight. The solvent was removed and methylene chloride was added, and the mixture was washed three times with aqueous NaOH. The organic phase was dried over MgSO4, filtered, and concentrated to afford the title compound as a yellow solid (400 mg, 94%).

후처리

  1. customThe solvent was removed
  2. additionmethylene chloride was added
  3. washthe mixture was washed three times with aqueous NaOH
  4. dry with materialThe organic phase was dried over MgSO4
  5. filtrationfiltered
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-c9ffd623938741d09dc6c387c3629060
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08604205B2

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