Adenine → 9-(4-nitro-phenyl)-9H-purin-6-ylamine

HRID 1912859

반응식

HRID 1912859 반응식
[N:1]1[C:9]([NH2:10])=[C:8]2[C:4]([N:5]=[CH:6][NH:7]2)=[N:3][CH:2]=1.CC(C)([O-])C.[K+].F[C:18]1[CH:23]=[CH:22][C:21]([N+:24]([O-:26])=[O:25])=[CH:20][CH:19]=1>CS(C)=O.O>[N+:24]([C:21]1[CH:22]=[CH:23][C:18]([N:5]2[CH:6]=[N:7][C:8]3[C:4]2=[N:3][CH:2]=[N:1][C:9]=3[NH2:10])=[CH:19][CH:20]=1)([O-:26])=[O:25]

참가 물질

6

반응물 3

HCID 190AdenineHCID 9590p-FluoronitrobenzeneHCID 23665647Potassium tert-butoxide

생성물 1

HCID 3090939-(4-nitro-phenyl)-9H-purin-6-ylamine수율 93.7%

시약·촉매·용매 2

HCID 679Dimethyl Sulfoxide용매HCID 962Water용매

반응 조건

온도
80 °C

실험 절차

In 100 ml of dimethyl sulfoxide, 4.05 g (30.0 mmol) of adenine was dissolved, and 3.5 g (31.0 mmol) of potassium tert-butoxide and 5.0 g (35.0 mmol) of 4-fluoronitrobenzene were added thereto, and the mixture solution was stirred at 80° C. for three hours. The solution was diluted with 200 mL of water and the precipitate formed was collected by filtration, washed with 100 mL of water and 30 mL of methanol in the order named and vacuum dried to obtain 7.2 g (84%) of a target product as a yellow solid.

후처리

  1. customthe precipitate formed
  2. filtrationwas collected by filtration
  3. washwashed with 100 mL of water and 30 mL of methanol in the order
  4. customvacuum dried

출처 및 근거

ORD 기록
ord-fc675b0af2b8458d801a87703d3d2378
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08609656B2

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