Hydrochloric Acid → 4-CarboxyMethyl-cyclohexanecarboxylic acid ethyl ester

HRID 1913213노트

반응식

HRID 1913213 반응식
C([O:5][C:6](=[O:19])[CH2:7][CH:8]1[CH2:13][CH2:12][CH:11]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH2:10][CH2:9]1)(C)(C)C.Cl>O1CCOCC1>[CH2:17]([O:16][C:14]([CH:11]1[CH2:12][CH2:13][CH:8]([CH2:7][C:6]([OH:19])=[O:5])[CH2:9][CH2:10]1)=[O:15])[CH3:18]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 66613615Ethyl 4-(2-tert-butoxy-2-oxoethyl)cyclohexanecarboxylate

생성물 1

HCID 158961924-CarboxyMethyl-cyclohexanecarboxylic acid ethyl ester

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

To a 100 mL round-bottom flask was charged ethyl 4-(2-tert-butoxy-2-oxoethyl)cyclohexanecarboxylate (Int-4b, 2.00 g, 7.40 mmol) and 4N HCl in 1,4-dioxane. The resulting solution was stirred at room temperature for 2 hours. At this point the solvent was removed in vacuo and the resulting residue was diluted with DCM and washed with H2O. The organic layer was dried over Na2SO4 and reduced in vacuo. The resulting residue was taken on without further purification.

후처리

  1. customAt this point the solvent was removed in vacuo
  2. additionthe resulting residue was diluted with DCM
  3. washwashed with H2O
  4. dry with materialThe organic layer was dried over Na2SO4
  5. customThe resulting residue was taken on without further purification

출처 및 근거

ORD 기록
ord-11b5d88ef7354042b7aaa5721929ff84
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08609675B2

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