Hydrochloric Acid → Ethyl 1-methyl-4-oxocyclohexanecarboxylate

HRID 1913235

반응식

HRID 1913235 반응식
[CH3:1][C:2]1([C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH2:11][CH2:10][C:5]2(OCC[O:6]2)[CH2:4][CH2:3]1.CCO.O.Cl>O1CCOCC1>[CH3:1][C:2]1([C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH2:3][CH2:4][C:5](=[O:6])[CH2:10][CH2:11]1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 962WaterHCID 19004805Ethyl 8-methyl-1,4-dioxaspiro[4.5]decane-8-carboxylate

생성물 1

HCID 21911973Ethyl 1-methyl-4-oxocyclohexanecarboxylate

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

In a 50 mL round-bottom flask was mixed with ethyl 8-methyl-1,4-dioxaspiro[4.5]decane-8-carboxylate (Int-6a, 1.99 g, 8.72 mmol), EtOH (10 mL), H2O (5 mL), and 4N HCl in 1,4-dioxane (5 mL). The resulting solution was stirred at room temperature for 64 hours. At this time, the solvent was removed in vacuo and the residue was taken up in DCM. The suspension was washed with saturated NaHCO3(aq) and the organic layer was dried over Na2SO4. The resulting product was taken on without further purification. Yield=1.00 g.

후처리

  1. customAt this time, the solvent was removed in vacuo
  2. washThe suspension was washed with saturated NaHCO3(aq)
  3. dry with materialthe organic layer was dried over Na2SO4
  4. customThe resulting product was taken on without further purification

출처 및 근거

ORD 기록
ord-d027fab779754691829fdfd85cf0c6a8
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08609675B2

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