Hydrochloric Acid → 2-Chloro-6-{[2-(4-chlorophenyl)-1,3-oxazol-4-yl]methoxy}-4-[4-(2-hydroxyethoxy)phenyl]-pyridine-3,5-dicarbonitrile

온도

60 °C

78 mg (0.67 mmol) of isopentyl nitrite and 90 mg (0.67 mmol) of copper(II) chloride were initially charged in 8.5 ml of acetonitrile, and 72 mg (0.64 mmol) of the compound from Example 49A were added. The reaction mixture was stirred at 60° C. for 3 h. 8.5 ml of 1N hydrochloric acid were added to the reaction solution. The aqueous phase was extracted twice with in each case 20 ml of ethyl acetate, and the combined organic phases were dried over magnesium sulfate. After removal of the solvent on a rotary evaporator, the residue was dried under reduced pressure and used without further purification for the subsequent reaction.

1. extractionThe aqueous phase was extracted twice with in each case 20 ml of ethyl acetate
2. dry with materialthe combined organic phases were dried over magnesium sulfate
3. customAfter removal of the solvent
4. customon a rotary evaporator
5. customthe residue was dried under reduced pressure
6. customused without further purification for the subsequent reaction

ORD 기록

ord-3632816299e44feab97006dcef0a7cfe

출처 데이터셋

uspto-grants-2013_12

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US08609686B2