Lithium Hydroxide → 2-(4-(Tert-butoxycarbonyl)phenyl)acetic acid

HRID 1913770노트

반응식

HRID 1913770 반응식
C[O:2][C:3](=[O:18])[CH2:4][C:5]1[CH:17]=[CH:16][C:8]([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])=[CH:7][CH:6]=1.[OH-].[Li+]>O.C1COCC1>[C:12]([O:11][C:9]([C:8]1[CH:7]=[CH:6][C:5]([CH2:4][C:3]([OH:18])=[O:2])=[CH:17][CH:16]=1)=[O:10])([CH3:15])([CH3:13])[CH3:14]

참가 물질

5

반응물 2

HCID 3939Lithium HydroxideHCID 57611856Tert-butyl 4-((methoxycarbonyl)methyl)benzoate

생성물 1

HCID 598545182-(4-(Tert-butoxycarbonyl)phenyl)acetic acid수율 90.6%

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매

실험 절차

A solution of 4.2 g (16.78 mmol) of tert-butyl 4-(2-methoxy-2-oxoethyl)benzoate in 50 ml of water and 50 ml of THF is mixed with 0.8 g (33.6 mmol) of lithium hydroxide and stirred at room temperature for 1 hour. The phases are separated and the aqueous phase is adjusted to pH 3 with 2 M hydrochloric acid. It is extracted with ethyl acetate. The organic phase is then washed with sodium chloride solution, dried over sodium sulphate and evaporated. 3.6 g (15.2 mmol, 87% yield) of the title compound are obtained.

후처리

  1. customThe phases are separated
  2. extractionIt is extracted with ethyl acetate
  3. washThe organic phase is then washed with sodium chloride solution
  4. dry with materialdried over sodium sulphate
  5. customevaporated

출처 및 근거

ORD 기록
ord-82a26dd3524d423295cd878441a65f93
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08609727B2

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