Pyrrolidine → 2-((S)-6-Pyrrolidin-1-ylmethyl-1,2,3,4-tetrahydronaphthalen-2-yl)-6-[(S)-1-(tetrahydrofuran-2-yl)methoxy]-3,4-dihydro-2H-isoquinolin-1-one
반응식
[O:1]=[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:12][CH2:13][C@@H:14]3[CH2:18][CH2:17][CH2:16][O:15]3)=[CH:9][CH:10]=2)[CH2:5][CH2:4][N:3]1[C@H:19]1[CH2:28][CH2:27][C:26]2[CH:25]=[C:24]([CH:29]=O)[CH:23]=[CH:22][C:21]=2[CH2:20]1.[NH:31]1[CH2:35][CH2:34][CH2:33][CH2:32]1>>[N:31]1([CH2:29][C:24]2[CH:25]=[C:26]3[C:21](=[CH:22][CH:23]=2)[CH2:20][C@@H:19]([N:3]2[CH2:4][CH2:5][C:6]4[C:11](=[CH:10][CH:9]=[C:8]([O:12][CH2:13][C@@H:14]5[CH2:18][CH2:17][CH2:16][O:15]5)[CH:7]=4)[C:2]2=[O:1])[CH2:28][CH2:27]3)[CH2:35][CH2:34][CH2:33][CH2:32]1참가 물질
3
반응물 2
생성물 1
실험 절차
According to method H-1, (S)-6-{1-oxo-6-[(S)-1-(tetrahydrofuran-2-yl)methoxy]-3,4-dihydro-1H-isoquinolin-2-yl}-5,6,7,8-tetrahydronaphthalene-2-carbaldehyde was reacted with pyrrolidine. The product was thus obtained with the molecular weight of 460.62 (C29H36N2O3); MS (ESI): 461 (M+H+).