참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | p-Toluenesulfonic acid | HCID 6101 | — |
| 반응물 | Sorafenib | HCID 216239 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Sorafenib Tosylate | HCID 406563 | 85.5% |
반응 단계
Sorafenib free base (3 g) was added to a solution of p-toluenesulphonic acid (14.4 g) in water (6 mL). The reaction mixture was stirred at about 30° C. for about 2 hours. The reaction mixture was filtered, washed with water (2×10 mL) and dried under reduced pressure at about 70° C. for about 12 hours to obtain sorafenib tosylate.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08609854B2 |
|---|
| 출처 데이터셋 | uspto-grants-2013_12 |
|---|
| ORD ID | ord-0e59618d4303487fbd46294dddc01eab |
|---|
| 출처 메모 | uspto-grants-2013_12 |
|---|
