反应详情

温度

30 °C

Sorafenib free base (3 g) was added to a solution of p-toluenesulphonic acid (14.4 g) in water (6 mL). The reaction mixture was stirred at about 30° C. for about 2 hours. The reaction mixture was filtered, washed with water (2×10 mL) and dried under reduced pressure at about 70° C. for about 12 hours to obtain sorafenib tosylate.

1. filtrationThe reaction mixture was filtered
2. washwashed with water (2×10 mL)
3. customdried under reduced pressure at about 70° C. for about 12 hours