Hydrazine hydrate (1:1) → HCID 178470478, 화합물
반응식
C([O:3][C:4]1[C:5](=O)[CH:6]([C:10](=O)[C:11]([O:13][CH2:14][CH3:15])=[O:12])[CH2:7][CH2:8][CH:9]=1)C.O.[NH2:19][NH2:20]>C(O)C>[O:3]=[C:4]1[C:5]2[NH:20][N:19]=[C:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])[C:6]=2[CH2:7][CH2:8][CH2:9]1참가 물질
4
실험 절차
10.0 g (42 mmol) of ethyl (3-ethoxy-2-oxocyclohex-3-en-1-yl)(oxo)acetate were dissolved in 100 mL of ethanol, 2.1 mL of hydrazine hydrate were added and the solution stirred at reflux for one day. The solvent was then evaporated and the residue redissolved with dichloromethane. The organic layer was washed with water, dried over Na2SO4 and concentrated. The crude was triturated with diethyl ether and filtered to give 6.0 g of the title compound (70% yield).
후처리
- temperatureat reflux for one day
- customThe solvent was then evaporated
- dissolutionthe residue redissolved with dichloromethane
- washThe organic layer was washed with water
- dry with materialdried over Na2SO4
- concentrationconcentrated
- customThe crude was triturated with diethyl ether
- filtrationfiltered
출처 및 근거
- ORD 기록
- ord-3da0bf00771942eb89d6632dc99a229a
- 출처 데이터셋
- uspto-grants-2013_12
- 특허 번호
- US08614220B2
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