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Trityl chloride → Diethyl Ether

HRID 1914730
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HRID 1914730 반응식
[O:1]=[C:2]1[C:10]2[NH:9][N:8]=[C:7]([C:11]([O:13][CH2:14][CH3:15])=[O:12])[C:6]=2[CH2:5][CH2:4][CH2:3]1.C(N(CC)CC)C.[C:23]1([C:29](Cl)([C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)[C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>ClCCl>[O:1]=[C:2]1[C:10]2[N:9]([C:29]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)([C:36]3[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=3)[C:30]3[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=3)[N:8]=[C:7]([C:11]([O:13][CH2:14][CH3:15])=[O:12])[C:6]=2[CH2:5][CH2:4][CH2:3]1.[CH2:11]([O:13][CH2:14][CH3:15])[CH3:7]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 6456Trityl chlorideHCID 8471TriethylamineHCID 178470478HCID 178470478, 화합물

생성물 2

HCID 3283Diethyl Ether수율 874.2%HCID 68668650HCID 68668650, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

2.08 g (10.0 mmol) of ethyl 7-oxo-4,5,6,7-tetrahydro-1H-indazole-3-carboxylate were dissolved in 100 mL of dichloromethane and 0.76 mL of triethylamine and 3.07 g (11.0 mmol) of triphenylmethyl chloride were added. The solution was stirred at room temperature for 6 hours. Then the solution was further diluted with dichloromethane and washed with water. The organic layer was treated with anhydrous Na2SO4 and evaporated to dryness. The final product was obtained by crystallization from diethyl ether (3.24 g, 72% yield).

후처리

  1. washwashed with water
  2. additionThe organic layer was treated with anhydrous Na2SO4
  3. customevaporated to dryness

출처 및 근거

ORD 기록
ord-d342f344adf64685abfcf473c402708d
출처 데이터셋
uspto-grants-2013_12
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08614220B2

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