Sodium Hydroxide → HCID 67112454, 화합물

HRID 1914808노트

반응식

HRID 1914808 반응식
[NH2:1][C@H:2]1[CH2:6][CH2:5][C@@H:4]([C:7]([OH:9])=[O:8])[CH2:3]1.[OH-].[Na+].[C:12](Cl)(=[O:15])[CH2:13][CH3:14]>C1COCC1>[C:12]([NH:1][C@H:2]1[CH2:6][CH2:5][C@@H:4]([C:7]([OH:9])=[O:8])[CH2:3]1)(=[O:15])[CH2:13][CH3:14]

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 62324Propionyl chlorideHCID 1502035Cyclopentanecarboxylic acid, 3-amino-, (1R,3S)-rel- (9CI)

생성물 1

HCID 67112454HCID 67112454, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

100.0 mg (0.77 mmol) (1R,3S)-3-Aminocyclopentane carboxylic acid is stirred in 2.0 mL THF and 0.77 mL (1.55 mmol) sodium hydroxide solution (2 mol/l). 74.0 μL (0.85 mmol) Propionyl chloride is added drop wise and the mixture is stirred at RT over night. The solvent is evaporated. The mixture is stirred at RT over night. The product is purified by RP-HPLC (water+5-95% acetonitrile (with addition of 0.1% TFA)) and lyophilized.

후처리

  1. customThe solvent is evaporated
  2. stirringThe mixture is stirred at RT over night
  3. customThe product is purified by RP-HPLC (water+5-95% acetonitrile (with addition of 0.1% TFA))

출처 및 근거

ORD 기록
ord-2cd22e7d56e74f918aad4ab623987221
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08614238B2

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