Potassium Carbonate → o-Cresol, 4-bromo-alpha,alpha,alpha-trifluoro-

HRID 1916557노트

반응식

HRID 1916557 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8]C)=[C:4]([C:10]([F:13])([F:12])[F:11])[CH:3]=1.C([O-])([O-])=O.[K+].[K+]>Br.C(O)(=O)C.O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[C:4]([C:10]([F:11])([F:12])[F:13])[CH:3]=1

참가 물질

6

반응물 2

HCID 11430Potassium CarbonateHCID 27753044-Bromo-1-methoxy-2-(trifluoromethyl)benzene

생성물 1

HCID 142784o-Cresol, 4-bromo-alpha,alpha,alpha-trifluoro-

시약·촉매·용매 3

HCID 176Acetic Acid용매HCID 260Hydrogen Bromide용매HCID 962Water용매

실험 절차

A solution of 3.0 g (11.8 mmol) 4-bromo-1-methoxy-2-trifluoromethyl-benzene in 20 mL 1 M HBr in glacial acetic acid is stirred for 60 h at 90° C. The reaction solution is diluted with 300 mL water, adjusted to pH 7 with K2CO3. The aqueous phase is extracted with EtOAc, the combined organic extracts are with washed 40 mL quarter-saturated NaHCO3 solution and dried over MgSO4. The solvent is eliminated i.vac. and the product is further reacted without any more purification.

후처리

  1. extractionThe aqueous phase is extracted with EtOAc
  2. washwith washed 40 mL quarter-saturated NaHCO3 solution
  3. dry with materialdried over MgSO4
  4. customand the product is further reacted without any more purification

출처 및 근거

ORD 기록
ord-e4995eef19f04a5cb427ef2e5989bcca
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08618132B2

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