5-nitro-1-(2-pyrrolidin-1-yl-ethyl)-1H-indazole → 1-(2-Pyrrolidin-1-YL-ethyl)-1H-indazol-5-ylamine

HRID 1916665노트

반응식

HRID 1916665 반응식
[N+:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[N:9]([CH2:13][CH2:14][N:15]1[CH2:19][CH2:18][CH2:17][CH2:16]1)[N:8]=[CH:7]2)([O-])=O>[Ni].CCOC(C)=O>[N:15]1([CH2:14][CH2:13][N:9]2[C:10]3[C:6](=[CH:5][C:4]([NH2:1])=[CH:12][CH:11]=3)[CH:7]=[N:8]2)[CH2:19][CH2:18][CH2:17][CH2:16]1

참가 물질

4

반응물 1

HCID 220365795-nitro-1-(2-pyrrolidin-1-yl-ethyl)-1H-indazole

생성물 1

HCID 113107771-(2-Pyrrolidin-1-YL-ethyl)-1H-indazol-5-ylamine

시약·촉매·용매 2

HCID 935Nickel촉매HCID 8857Ethyl Acetate용매

실험 절차

0.50 g Raney nickel are added to a solution of 3.50 g (13.4 mmol) 5-nitro-1-(2-pyrrolidin-1-yl-ethyl)-1H-indazole in 50 mL EtOAc and the reaction mixture is stirred for 20 h at RT at 1.4 bar H2. After filtration the solvent is eliminated i.vac. The product is further reacted without any more purification.

후처리

  1. filtrationAfter filtration the solvent
  2. customThe product is further reacted without any more purification

출처 및 근거

ORD 기록
ord-bf897fffa7a9484e967c5bb41ad61533
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08618132B2

반응 노트

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