Stannous Chloride → 2-Bromo-5-(4-chloro-phenyl)-pyridin-3-ylamine

HRID 1916674노트

반응식

HRID 1916674 반응식
[Br:1][C:2]1[C:7]([N+:8]([O-])=O)=[CH:6][C:5]([C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=2)=[CH:4][N:3]=1.[Sn](Cl)Cl.C([O-])(O)=O.[Na+]>CCOC(C)=O>[Br:1][C:2]1[C:7]([NH2:8])=[CH:6][C:5]([C:11]2[CH:12]=[CH:13][C:14]([Cl:17])=[CH:15][CH:16]=2)=[CH:4][N:3]=1

참가 물질

5

반응물 3

HCID 24479Stannous ChlorideHCID 516892Sodium BicarbonateHCID 859696992-Bromo-5-(4-chlorophenyl)-3-nitropyridine

생성물 1

HCID 859697042-Bromo-5-(4-chloro-phenyl)-pyridin-3-ylamine

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

A solution of 5.60 g (17.9 mmol) 2-bromo-5-(4-chloro-phenyl)-3-nitro-pyridine, 20.3 g (90.0 mmol) tin(II)-chloride and 18.9 g (225 mmol) NaHCO3 in 300 mL EtOAc is refluxed for 30 h. After filtration the solvent is eliminated i.vac. The residue is triturated with DCM and after filtration the filter residue is dried in the air.

후처리

  1. filtrationAfter filtration the solvent
  2. customThe residue is triturated with DCM
  3. filtrationafter filtration the filter residue
  4. customis dried in the air

출처 및 근거

ORD 기록
ord-b841da7b84814a379a6b0c6a8e1534bf
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08618132B2

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