Potassium Carbonate → 5-Bromo-2-pyrrolidin-1-ylmethyl-benzoxazole

HRID 1916761노트

반응식

HRID 1916761 반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([CH2:10]Cl)=[N:7][C:6]=2[CH:12]=1.C([O-])([O-])=O.[K+].[K+].[NH:19]1[CH2:23][CH2:22][CH2:21][CH2:20]1>CN(C=O)C.O>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([CH2:10][N:19]3[CH2:23][CH2:22][CH2:21][CH2:20]3)=[N:7][C:6]=2[CH:12]=1

참가 물질

6

반응물 3

HCID 11430Potassium CarbonateHCID 31268PyrrolidineHCID 142042085-Bromo-2-(chloromethyl)-1,3-benzoxazole

생성물 1

HCID 673655735-Bromo-2-pyrrolidin-1-ylmethyl-benzoxazole

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

실험 절차

A solution of 2 g (8.11 mmol) 5-bromo-2-chloromethyl-benzoxazole in 30 mL DMF is combined with 2.24 g (16.22 mmol) K2CO3 and 0.9 mL (10.78 mmol) pyrrolidine and stirred for 24 hours at RT. The reaction mixture is diluted with water and extracted with EtOAc. The organic phase is dried over Na2SO4, the desiccant is filtered off and the filtrate is evaporated down.

후처리

  1. extractionextracted with EtOAc
  2. dry with materialThe organic phase is dried over Na2SO4
  3. filtrationthe desiccant is filtered off
  4. customthe filtrate is evaporated down

출처 및 근거

ORD 기록
ord-60132da22cba45ec88c52177cc03b648
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08618132B2

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