Sodium Hydroxide → HCID 67490897, 화합물

HRID 1917370노트

반응식

HRID 1917370 반응식
[OH-].[Na+].C[O:4][C:5]([C:7]12[CH2:14][CH2:13][CH:12]=[C:11]1[CH2:10][N:9]([C:15]([O:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[O:16])[CH2:8]2)=[O:6]>CO>[CH2:18]([O:17][C:15]([N:9]1[CH2:10][C:11]2[C:7]([C:5]([OH:6])=[O:4])([CH2:14][CH2:13][CH:12]=2)[CH2:8]1)=[O:16])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 67490992HCID 67490992, 화합물

생성물 1

HCID 67490897HCID 67490897, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A 1N sodium hydroxide solution (1.86 mL) was added to a solution of {3-benzyloxycarbonyl-3-azabicyclo[3.3.0]oct-5-en-1-yl}carboxylic acid methyl ester (187 mg, 0.620 mmol) in methanol (6.20 mL) in a nitrogen atmosphere, and the mixture was stirred at room temperature for 16 hours. The reaction solution was concentrated under reduced pressure and then washed with diethyl ether (50 mL×2). The aqueous layer was made acidic with 1N hydrochloric acid under ice-cooling, followed by extraction with ethyl acetate (100 mL×1, 80 mL×1). The organic layer was washed with water (80 mL) and brine (80 mL) and dried over anhydrous sodium sulfate. After filtration, the filtrate was concentrated under reduced pressure to give 186 mg (quantitative) of the title compound.

후처리

  1. concentrationThe reaction solution was concentrated under reduced pressure
  2. washwashed with diethyl ether (50 mL×2)
  3. temperaturecooling
  4. extractionfollowed by extraction with ethyl acetate (100 mL×1, 80 mL×1)
  5. washThe organic layer was washed with water (80 mL) and brine (80 mL)
  6. dry with materialdried over anhydrous sodium sulfate
  7. filtrationAfter filtration
  8. concentrationthe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-f81bd2e0f9024a2b86ed0729f8a26cfd
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08618094B2

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