Hydrochloric Acid → HCID 67170485, 화합물

HRID 1918282노트

반응식

HRID 1918282 반응식
[CH3:1][O:2][C:3]([C:5]1([NH:12][C:13](=[O:26])[C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[C:16]([O:22]C(=O)C)[CH:15]=2)[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1)=[O:4].C(=O)([O-])[O-].[K+].[K+].Cl>CO>[CH3:1][O:2][C:3]([C:5]1([NH:12][C:13](=[O:26])[C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[C:16]([OH:22])[CH:15]=2)[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11]1)=[O:4]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 11430Potassium CarbonateHCID 866725641-(3-Acetoxy-4-methoxy-benzoylamino)-Cycloheptanecarboxylic Acid Methyl Ester

생성물 1

HCID 67170485HCID 67170485, 화합물수율 72.1%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

The compound of step 1 (10.6 g, 29.4 mmol) was dissolved in methanol (100 ml), potassium carbonate (812 mg, 5.88 mmol) was added and the mixture was stirred overnight at room temperature. An excess of 2 N hydrochloric acid was added, the methanol was evaporated in vacuo and the residue partitioned between EA and water. The aqueous phase was extracted with EA, the combined organic phases were dried over sodium sulfate and evaporated to dryness to give the title compound (6.81 g).

후처리

  1. customthe methanol was evaporated in vacuo
  2. customthe residue partitioned between EA and water
  3. extractionThe aqueous phase was extracted with EA
  4. dry with materialthe combined organic phases were dried over sodium sulfate
  5. customevaporated to dryness

출처 및 근거

ORD 기록
ord-7d09f115fc0144c0ab3a8817a0aabdf9
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08618304B2

반응 노트

불러오는 중…