Methanol → 5-Bromo-6-methoxy-3-pyridinecarboxylic acid

HRID 1918312노트

반응식

HRID 1918312 반응식
C[O:2][C:3](=[O:13])[C:4]1[CH:9]=[C:8]([Br:10])[C:7]([O:11][CH3:12])=[N:6][CH:5]=1.[OH-].[Li+].CO>O1CCOCC1.O>[Br:10][C:8]1[C:7]([O:11][CH3:12])=[N:6][CH:5]=[C:4]([CH:9]=1)[C:3]([OH:13])=[O:2]

참가 물질

6

반응물 3

HCID 887MethanolHCID 3939Lithium HydroxideHCID 46311221Methyl 5-bromo-6-methoxypyridine-3-carboxylate

생성물 1

HCID 457904665-Bromo-6-methoxy-3-pyridinecarboxylic acid

시약·촉매·용매 2

HCID 962Water용매HCID 312751,4-Dioxane용매

반응 조건

온도
60 °C

실험 절차

5-Bromo-6-methoxy-nicotinic acid methyl ester (W. J. Thompson et al., J. Org. Chem. 49 (1984), 5237-5243; 2.00 g, 8.13 mmol) was dissolved in dioxane (40 ml), lithium hydroxide (40 ml of a 1 M solution in water) was added and subsequently sufficient methanol to achieve complete dissolution. The mixture was stirred at 60° C. for 2 h.

후처리

  1. dissolutiondissolution

출처 및 근거

ORD 기록
ord-97baeb2699174942a3eed506997b79bf
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08618304B2

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