Sodium Hydroxide → 4-Oxetan-3-yl-3-(2-m-tolyl-ethoxy)-benzoic Acid

HRID 1918333노트

반응식

HRID 1918333 반응식
C([O:4][C:5](=[O:26])[C:6]1[CH:11]=[CH:10][C:9]([CH:12]2[CH2:15][O:14][CH2:13]2)=[C:8]([O:16][CH2:17][CH2:18][C:19]2[CH:20]=[C:21]([CH3:25])[CH:22]=[CH:23][CH:24]=2)[CH:7]=1)(C)C.[OH-].[Na+]>CO>[O:14]1[CH2:15][CH:12]([C:9]2[CH:10]=[CH:11][C:6]([C:5]([OH:26])=[O:4])=[CH:7][C:8]=2[O:16][CH2:17][CH2:18][C:19]2[CH:20]=[C:21]([CH3:25])[CH:22]=[CH:23][CH:24]=2)[CH2:13]1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 671701384-Oxetan-3-yl-3-(2-m-tolyl-ethoxy)-benzoic Acid Isopropyl Ester

생성물 1

HCID 671687094-Oxetan-3-yl-3-(2-m-tolyl-ethoxy)-benzoic Acid수율 99.3%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

120 mg of 4-oxetan-3-yl-3-(2-m-tolyl-ethoxy)-benzoic acid isopropyl ester were dissolved in 3 ml of methanol and 0.2 ml of a 2 N aqueous solution of sodium hydroxide added. The mixture was left at room temperature for 6 days and then evaporated. The residue was dissolved in 10 ml of water, the pH adjusted to 2 with an aqueous sodium hydrogensulfate solution, and the mixture extracted three times using 20 ml each of DCM. The combined extracts were dried with magnesium sulfate and evaporated to yield 105 mg of the title compound.

후처리

  1. customevaporated
  2. dissolutionThe residue was dissolved in 10 ml of water
  3. extractionthe mixture extracted three times
  4. dry with materialThe combined extracts were dried with magnesium sulfate
  5. customevaporated

출처 및 근거

ORD 기록
ord-c8d2e2a4461d48e29d093d79975bbc1f
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08618304B2

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