Hydroxyamine hydrochloride → tert-Butyl 2-Amino-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate

HRID 1918908노트

반응식

HRID 1918908 반응식
C1(C(=[N:14][C:15]2[CH:24]=[CH:23][C:22]3[CH2:21][N:20]([C:25]([O:27][C:28]([CH3:31])([CH3:30])[CH3:29])=[O:26])[CH2:19][CH2:18][C:17]=3[N:16]=2)C2C=CC=CC=2)C=CC=CC=1.NO.Cl>CO>[NH2:14][C:15]1[CH:24]=[CH:23][C:22]2[CH2:21][N:20]([C:25]([O:27][C:28]([CH3:31])([CH3:30])[CH3:29])=[O:26])[CH2:19][CH2:18][C:17]=2[N:16]=1

참가 물질

4

반응물 2

HCID 443297Hydroxyamine hydrochlorideHCID 58043757tert-Butyl 2-(Diphenylmethyleneamino)-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate

생성물 1

HCID 58043778tert-Butyl 2-Amino-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Intermediate 158a was added to a round-bottomed flask. MeOH (50 mL) and NH2OH HCl (1.76 g, 25.3 mmol) was added. The resulting mixture was stirred at RT for 5 hrs. The solvents were removed in vacuo and silica gel column (MeOH:DCM=10:90) gave 158b as dark oil, 851 mg (84%, 2 steps).

후처리

  1. customThe solvents were removed in vacuo and silica gel column (MeOH:DCM=10:90)

출처 및 근거

ORD 기록
ord-a58c1480639f4ce4b82b6516603f683b
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08618107B2

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