Sodium Hydroxide → (3R)-1-benzylpiperidin-3-amine

반응식

[OH-].[Na+].[CH2:3]([N:10]1[CH2:15][CH2:14][CH2:13][CH:12]([NH2:16])[CH2:11]1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1>>[CH2:3]([N:10]1[CH2:15][CH2:14][CH2:13][C@@H:12]([NH2:16])[CH2:11]1)[C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

참가 물질

반응물 2

HCID 14798Sodium Hydroxide

HCID 4216941-Benzylpiperidin-3-amine

생성물 1

HCID 854130(3R)-1-benzylpiperidin-3-amine

실험 절차

After the reaction liquid had been adjusted to a pH of 13 by the addition of 5 N aqueous solution of sodium hydroxide, N-benzyl-3-aminopiperidine was extracted with 1 L of toluene, and was then further extracted from the aqueous phase with 1 L of toluene. After the solvent had been distilled under reduced pressure away from a combination of the organic phases thus obtained, (R)—N-benzyl-3-aminopiperidine was purified by distillation. Thus, 17.7 g of (R)—N-benzyl-3-aminopiperidine were obtained in the form of colorless oil.

후처리

customAfter the reaction liquid
extractionwas extracted with 1 L of toluene
extractionwas then further extracted from the aqueous phase with 1 L of toluene
distillationAfter the solvent had been distilled under reduced pressure away from a combination of the organic phases
customthus obtained
distillation(R)—N-benzyl-3-aminopiperidine was purified by distillation

출처 및 근거

ORD 기록: ord-4749465784144f8eb73f5db807003993
출처 데이터셋: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08168412B2

반응 노트

불러오는 중…