N-bromobutanimide → 2-(Bromomethyl)-5-(2'-methoxy-5'-fluorophenyl)tetrahydrofuran
반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([F:9])=[CH:5][C:4]=1[CH:10]([OH:15])[CH2:11][CH2:12][CH:13]=[CH2:14].[Br:16]N1C(=O)CCC1=O>C(Cl)Cl>[Br:16][CH2:14][CH:13]1[CH2:12][CH2:11][CH:10]([C:4]2[CH:5]=[C:6]([F:9])[CH:7]=[CH:8][C:3]=2[O:2][CH3:1])[O:15]1참가 물질
4
실험 절차
To a solution of 1-(2′-methoxy-5′-fluorophenyl)pent-4-en-1-ol (3.24 g, 18.0 mmol) in dry CH2Cl2 (50 mL) at 0° C. was added portionwise N-bromosuccinimide (NBS, 3.56 g, 20.0 mmol) portionwise and the reaction was warmed to room temperature for 12 h. Solvent was then removed in vacuo and the residue was purified by flash column chromatography (10% EtOAc in Hexane, Rf=0.28) to give the product (2.28 g, 44%) as an oil.
후처리
- customSolvent was then removed in vacuo
- customthe residue was purified by flash column chromatography (10% EtOAc in Hexane, Rf=0.28)
출처 및 근거
- ORD 기록
- ord-5cf6613acdeb4b2ab32af2cda0136a6e
- 출처 데이터셋
- uspto-grants-2012_05
- 특허 번호
- US08168635B2
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