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Sodium borohydride → [1-(6-Tert-butyl-2-methoxypyridin-3-yl)ethyl]amine

HRID 1919836
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HRID 1919836 반응식
[C:1]([C:5]1[N:10]=[CH:9][C:8]([CH:11]([NH2:13])[CH3:12])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].C(C1C=CC(C#N)=[C:20]([O:26]C)N=1)(C)(C)C.C[Mg+].[Br-].C1(C)C=CC=CC=1.C1COCC1.[BH4-].[Na+]>>[C:1]([C:5]1[N:10]=[C:9]([O:26][CH3:20])[C:8]([CH:11]([NH2:13])[CH3:12])=[CH:7][CH:6]=1)([CH3:4])([CH3:2])[CH3:3]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 5

HCID 4311764Sodium borohydrideHCID 22635083Tetrahydrofuran tolueneHCID 667452296-Tert-butyl-2-methoxynicotinonitrile2회HCID 67500288[1-(6-Tert-butylpyridin-3-yl)ethyl]amineHCID 178418689HCID 178418689, 화합물

생성물 1

HCID 67499814[1-(6-Tert-butyl-2-methoxypyridin-3-yl)ethyl]amine
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실험 절차

The title compound was synthesized according to the procedure described for the synthesis of [1-(6-tert-butylpyridin-3-yl)ethyl]amine starting from 6-tert-butyl-2-methoxynicotinonitrile (intermediate 23) (66 mg, 0.347 mmol), MeMgBr 1.4 M 75/25 toluene/THF (743 μL, 1.04 mmol) and NaBH4 (32.8 mg, 0.87 mmol Material isolated from the workup was used without further purification in the preparation.

후처리

  1. customisolated from the workup
  2. customwas used without further purification in the preparation

출처 및 근거

ORD 기록
ord-0e4bc44383f74a4dbcbaff24d437378a
출처 데이터셋
uspto-grants-2012_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08168668B2

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