Trifluoroacetic acid → (R)-1-Carboxymethyl-3-(2-hydroxy-2,2-diphenyl-acetoxy)-1-azonia-bicyclo[2.2.2]-octane trifluoroacetate

HRID 1920550노트

반응식

HRID 1920550 반응식
[Br-].C([O:6][C:7]([CH2:9][N+:10]12[CH2:17][CH2:16][CH:13]([CH2:14][CH2:15]1)[C@@H:12]([O:18][C:19](=[O:34])[C:20]([OH:33])([C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[CH2:11]2)=[O:8])(C)(C)C.[F:35][C:36]([F:41])([F:40])[C:37]([OH:39])=[O:38]>C(Cl)(Cl)Cl>[F:35][C:36]([F:41])([F:40])[C:37]([O-:39])=[O:38].[C:7]([CH2:9][N+:10]12[CH2:17][CH2:16][CH:13]([CH2:14][CH2:15]1)[C@@H:12]([O:18][C:19](=[O:34])[C:20]([OH:33])([C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1)[C:27]1[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1)[CH2:11]2)([OH:8])=[O:6]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 86611354(R)-1-tert-Butoxycarbonylmethyl-3-(2-hydroxy-2,2-diphenyl-acetoxy)-1-azonia-bicyclo[2.2.2]-octane bromide

생성물 1

HCID 86611356(R)-1-Carboxymethyl-3-(2-hydroxy-2,2-diphenyl-acetoxy)-1-azonia-bicyclo[2.2.2]-octane trifluoroacetate

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

To a stirred solution of (R)-1-tert-Butoxycarbonylmethyl-3-(2-hydroxy-2,2-diphenyl-acetoxy)-1-azonia-bicyclo[2.2.2]octane bromide (Example 60) (0.14 g, 0.264 mmol) in chloroform (5 ml) is added trifluoroacetic acid (1 ml). The reaction mixture is left to stir at room temperature overnight. The solvent is removed in vacuo and purification of the residue by chromatography on C18 silica, eluting with water:acetonitrile affords the titled compound as a white solid.

후처리

  1. waitThe reaction mixture is left
  2. customThe solvent is removed in vacuo and purification of the residue by chromatography on C18 silica
  3. washeluting with water

출처 및 근거

ORD 기록
ord-08015c63889546c8a5c9ec6bfaa69c0f
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08168654B2

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