Acetic acid, 2-(triphenylphosphoranylidene)-, ethyl ester → Ethyl 2-(oxetan-3-ylidene)acetate

HRID 1920864노트

반응식

HRID 1920864 반응식
[O:1]1[CH2:4][C:3](=O)[CH2:2]1.C1(P(C2C=CC=CC=2)(C2C=CC=CC=2)=[CH:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])C=CC=CC=1>C(Cl)Cl>[O:1]1[CH2:2][C:3](=[CH:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH2:4]1

참가 물질

4

반응물 2

HCID 70670Acetic acid, 2-(triphenylphosphoranylidene)-, ethyl esterHCID 150242543-Oxetanone

생성물 1

HCID 53308471Ethyl 2-(oxetan-3-ylidene)acetate수율 82.6%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of oxetan-3-one (500 mg, 6.938 mmol) in DCM (15.00 mL) at 0° C. was added ethyl 2-triphenylphosphoranylideneacetate (2.659 g, 7.632 mmol). The solution was allowed to warm to room temperature and stirred for 15 minutes. The reaction mixture was then filtered through a pad of silica (washing with 30% EtOAc:Petrol ether). and the solvent removed under reduced pressure to give ethyl 2-(oxetan-3-ylidene)acetate as a colourless viscous oil (815 mg, 79%).

후처리

  1. filtrationThe reaction mixture was then filtered through a pad of silica (washing with 30% EtOAc:Petrol ether)
  2. customand the solvent removed under reduced pressure

출처 및 근거

ORD 기록
ord-0755449bc2ce460d9cb58e12e43398c9
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08173635B2

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