N-(4-methyl-3-nitrophenyl)cyclopropanecarboxamide → N-(3-amino-4-methylphenyl)cyclopropanecarboxamide

HRID 1921286

반응식

HRID 1921286 반응식
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([CH:11]2[CH2:13][CH2:12]2)=[O:10])=[CH:4][C:3]=1[N+:14]([O-])=O.[H][H]>CO.[Pd]>[NH2:14][C:3]1[CH:4]=[C:5]([NH:8][C:9]([CH:11]2[CH2:13][CH2:12]2)=[O:10])[CH:6]=[CH:7][C:2]=1[CH3:1]

참가 물질

5

반응물 2

HCID 4104437N-(4-methyl-3-nitrophenyl)cyclopropanecarboxamideHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 24693537N-(3-amino-4-methylphenyl)cyclopropanecarboxamide수율 94.8%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

N-(4-Methyl-3-nitrophenyl)cyclopropanecarboxamide (409 mg) was hydrogenated over 10% Pd/C (50% wet, 80 mg) at atmospheric pressure of hydrogen in MeOH (20 mL) for 5 hr. The catalyst was removed by filtration through Celite® pad and the filtrate was evaporated in vacuo to give N-(3-amino-4-methylphenyl)cyclopropanecarboxamide (335 mg).

후처리

  1. customThe catalyst was removed by filtration through Celite® pad
  2. customthe filtrate was evaporated in vacuo

출처 및 근거

ORD 기록
ord-1148f2f8c34e49a9a37dc682729e6a91
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08173684B2

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