Sodium Hydroxide → HCID 57654546, 화합물
반응식
[OH-].[Na+].C([O:5][C:6](=[O:23])[CH:7]([C:13]1[CH:14]=[C:15]2[C:20](=[CH:21][CH:22]=1)[N:19]=[CH:18][N:17]=[CH:16]2)C(OCC)=O)C>CO>[N:19]1[C:20]2[C:15](=[CH:14][C:13]([CH2:7][C:6]([OH:23])=[O:5])=[CH:22][CH:21]=2)[CH:16]=[N:17][CH:18]=1참가 물질
4
실험 절차
Sodium hydroxide [2M] (0.77 mL) was added to a solution of 2-quinazolin-6-yl-malonic acid diethyl ester (0.20 g, 0.77 mmol) in methanol (10 mL) and stirred at room temperature for several hours. The reaction was evaporated, ethyl acetate was added and then 1N HCl was added dropwise until the compound went into the organic layer. The organic layer was evaporated to give 0.123 g (85%) of quinazolin-6-yl-acetic acid. 1H NMR (400 MHz, DMSO-d6) δ 9.56 (s, 1H), 9.26 (s, 1H), 7.95 (m, 3H), 3.85 (s, 2H).
후처리
- customThe reaction was evaporated
- additionethyl acetate was added
- addition1N HCl was added dropwise until the compound
- customThe organic layer was evaporated
출처 및 근거
- ORD 기록
- ord-f02eee87c62b49b1bb788266ff672fdf
- 출처 데이터셋
- uspto-grants-2012_05
- 특허 번호
- US08173654B2
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