Hydrochloric Acid → 4-(4-amino-6-methoxynaphthalen-2-yl)-N,N-dimethylpyrimidin-2-amine hydrochloride

HRID 1921974노트

반응식

HRID 1921974 반응식
[CH3:1][N:2]([CH3:29])[C:3]1[N:8]=[C:7]([C:9]2[CH:10]=[C:11]([NH:21]C(=O)OC(C)(C)C)[C:12]3[C:17]([CH:18]=2)=[CH:16][CH:15]=[C:14]([O:19][CH3:20])[CH:13]=3)[CH:6]=[CH:5][N:4]=1.[ClH:30].C(OCC)C>ClCCl.O1CCOCC1>[ClH:30].[NH2:21][C:11]1[C:12]2[C:17](=[CH:16][CH:15]=[C:14]([O:19][CH3:20])[CH:13]=2)[CH:18]=[C:9]([C:7]2[CH:6]=[CH:5][N:4]=[C:3]([N:2]([CH3:1])[CH3:29])[N:8]=2)[CH:10]=1

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 68288489HCID 68288489, 화합물

생성물 1

HCID 673061954-(4-amino-6-methoxynaphthalen-2-yl)-N,N-dimethylpyrimidin-2-amine hydrochloride

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 312751,4-Dioxane용매

실험 절차

To a solution of tert-butyl (3-(2-(dimethylamino)pyrimidin-4-yl)-7-methoxynaphthalen-1-yl)carbamate (140) (261 mg, 0.66 mmol) in dichloromethane (5 ml) was added 4 M hydrochloric acid in dioxane (2 ml). The mixture was stirred at room temperature for 24 hours. Diethylether (100 ml) was added and the solid filtered off and dried under vacuum to give 4-(4-amino-6-methoxynaphthalen-2-yl)-N,N-dimethylpyrimidin-2-amine (141) as a yellow solid.

후처리

  1. filtrationthe solid filtered off
  2. customdried under vacuum

출처 및 근거

ORD 기록
ord-9395e3688eb64c218241136d63b20b39
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08173808B2

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