3-Acetyl-6-methylpyridine → 1-(6-Methylpyridin-3-yl)ethan-1-ol

HRID 1922294

반응식

HRID 1922294 반응식
[CH3:1][C:2]1[N:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][CH:3]=1.[BH4-].[Na+]>C(O)C>[CH3:1][C:2]1[N:7]=[CH:6][C:5]([CH:8]([OH:10])[CH3:9])=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 952923-Acetyl-6-methylpyridineHCID 4311764Sodium borohydride

생성물 1

HCID 101299891-(6-Methylpyridin-3-yl)ethan-1-ol수율 79.8%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
0 °C

실험 절차

To a stirring solution of 1-(6-methyl-3-pyridinyl)ethanone (1.0 g, 7.4 mmol) in absolute ethanol (10 ml) at 0° C. was added sodium borohydride (0.14 g, 3.7 mmol) portionwise over 20 minutes. The reaction mixture was stirred at 0° C. for 1.5 hours before warming to room temperature. The mixture was partitioned between dichloromethane and saturated aqueous sodium hydrogen carbonate. The organic phase was dried over sodium sulphate, filtered, and evaporated in vacuo to give the crude product 1-(6-methyl-3-pyridinyl)ethanol (810 mg).

후처리

  1. temperaturebefore warming to room temperature
  2. customThe mixture was partitioned between dichloromethane and saturated aqueous sodium hydrogen carbonate
  3. dry with materialThe organic phase was dried over sodium sulphate
  4. filtrationfiltered
  5. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-33d182ab243f429f93c23547167915af
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08173820B2

연결된 노트

불러오는 중…