Diethyl Ether → Quinuclidin-4-ylmethanamine
반응식
[C:1]([C:3]12[CH2:10][CH2:9][N:6]([CH2:7][CH2:8]1)[CH2:5][CH2:4]2)#[N:2].[H-].[Al+3].[Li+].[H-].[H-].[H-].C(OCC)C.[OH-].[Na+]>O1CCCC1.O>[NH2:2][CH2:1][C:3]12[CH2:10][CH2:9][N:6]([CH2:7][CH2:8]1)[CH2:5][CH2:4]2참가 물질
7
실험 절차
4- Cyanoquinuclidine (0.31 g, 0.0028 moles) was reduced with lithium aluminium hydride (0.45 g, 0.012 moles) in tetrahydrofuran (20 ml) at ambient temperature for 18 hours. Diethyl ether (20 mls) was added followed by water (1.8 ml) and 10%w/v aqueous sodium hydroxide (0.68 ml) and the mixture stirred for 30 minutes. The mixture was then filtered and the filtrate concentrated in vacuo to give the title compound 0.3 g (94%).
후처리
- filtrationThe mixture was then filtered
- concentrationthe filtrate concentrated in vacuo
출처 및 근거
- ORD 기록
- ord-bbaeeaf588c64c02960459fd74f88c51
- 출처 데이터셋
- uspto-grants-2012_05
- 특허 번호
- USRE043390E1
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