참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Propane sultone | HCID 14264 | — |
| 반응물 | 1,2,3,4-Tetrahydroquinolin-5-ol | HCID 3046036 | — |
| 용매 | Butyronitrile | HCID 8008 | — |
| 생성물 | 3-(5-Hydroxy-3,4-dihydro-2h-quinoline-1-yl)propanesulfonic acid | HCID 59141708 | — |
반응 단계
A mixture of 0.8 g (5.36 mmol) of 5-hydroxy-1,2,3,4-tetrahydroquinoline and 0.5 g 1,3-propanesultone (4.1 mmol) in 12 ml of butyronitrile was heated at 125° C. for hours. The mixture was suction filtered and the filtrate evaporated under reduced pressure. The resulting off white compound crystallized. Product washed with ethyl ether and filtered of. Yield 0.8 g (80%)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08178360B2 |
|---|
| 출처 데이터셋 | uspto-grants-2012_05 |
|---|
| ORD ID | ord-4f75fb939d874ca8b65e784e6f4dfb10 |
|---|
| 출처 메모 | uspto-grants-2012_05 |
|---|
