4-Carboxychalcone → HCID 22251491, 화합물

HRID 1923465노트

반응식

HRID 1923465 반응식
[O:1]=[C:2]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[CH:3]=[CH:4][C:5]1[CH:13]=[CH:12][C:8]([C:9]([OH:11])=[O:10])=[CH:7][CH:6]=1>[Ni].C(O)C>[O:1]=[C:2]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[CH2:3][CH2:4][C:5]1[CH:13]=[CH:12][C:8]([C:9]([OH:11])=[O:10])=[CH:7][CH:6]=1

참가 물질

4

반응물 1

HCID 39957814-Carboxychalcone

생성물 1

HCID 22251491HCID 22251491, 화합물수율 59.9%

시약·촉매·용매 2

HCID 935Nickel촉매HCID 702Ethanol용매

실험 절차

4-(3-Oxo-3-phenyl-propenyl)-benzoic acid (7.64 g, 30 mmol) is combined with Raney nickel (2 g) in ethanol (140 mL). The mixture is hydrogenated at room temperature and 50 psi for 1.5 h. The reaction is filtered evaporated in vacuo. The resulting residue is recrystallized from ethyl acetate to obtain 4.57 g (59%) of the titled compound. m.p.=145-147° C.; Anal. Calcd for C16H14O3: C, 75.58; H, 5.55. Found: C, 75.60; H, 5.32.

후처리

  1. customis hydrogenated at room temperature
  2. filtrationThe reaction is filtered
  3. customevaporated in vacuo
  4. customThe resulting residue is recrystallized from ethyl acetate

출처 및 근거

ORD 기록
ord-d8ef56805cad48769ca5617b918e30b8
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08178528B2

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